We recently flew on the Qantas A380 from Sydney to Los Angeles in Business Class after first visiting the Qantas Sydney International Business Class Lounge.
The A380 has First Class and Economy on the lower level and Qantas Business Class upstairs along with a small cabin of Premium Economy and Economy. Being in Business Class, we entered the A380 via the top level after first skipping the long lines with Priority Immigration and Priority Boarding. Business Class is split into two cabins, a smaller one up front with 20 seats and a second cabin of 50 seats. I was seated in 20F, a middle seat in the second cabin.
The cabin is a 1-2-1 layout with all seats having direct aisle access and overhead storage on the sides and down the middle. All seats are facing forward but alternate in the location of the seat next to the aisle with the table on the left or the table next to the aisle with the seat on the left. There is no difference for couples when choosing middle seats as they are all separated by one table however there is a divider that can be lowered for couples travelling together. There is a large space for legroom and a deep footwell for sleeping later in the flight.